Professor Barry Marshall AC FRACP FRS FAA ( 30 September 1951 - ) Nobel Laureate 2005 - Medical Laboratory Scientist & Gastroenterologist
Introduction Professor Barry Marshall is a Nobel Laureate, Clinical Professor and UWA Brand Ambassador at The University of Western Australia. Professor Marshall (1974 UWA graduate) and Emeritus Professor J Robin Warren were awarded the 2005 Nobel Prize for Physiology or Medicine for their discovery of the bacterium Helicobacter pylori (H. pylori) and its role in gastritis and peptic ulcer disease. Marshall and Prof. Robin Warren showed that the bacterium
Helicobacter pylori (H. pylori) plays a major role in causing many peptic
ulcers, challenging decades of medical doctrine holding that ulcers were
caused primarily by stress, spicy foods, and too much acid. This discovery
has allowed for a breakthrough in understanding a causative link between
Helicobacter pylori infection and stomach cancer. Education Marshall was born in Kalgoorlie, Western Australia and lived in Kalgoorlie and Carnarvon until moving to Perth at the age of eight. His father held various jobs, and his mother was a nurse. He is the eldest of four siblings. He attended Newman College for his secondary education and the University of Western Australia School of Medicine, where he received a Bachelor of Medicine, Bachelor of Surgery (MBBS) in 1974. He married his wife Adrienne in 1972 and has four children.
Marshall obtained a bachelor’s degree from the University of Western
Australia in 1974. From 1977 to 1984 he worked at Royal Perth Hospital, and
he later taught medicine at the University of Western Australia, where he
also was a research fellow. Opportunities & Experiences
This contradicted the commonly held belief that peptic ulcers resulted from an excess of gastric acid that was released in the stomach as the result of emotional stress, the ingestion of spicy foods, or other factors. It also challenged the traditional treatments, which included antacid medicines and dietary changes, by supporting a curative regimen of antibiotics and acid-secretion inhibitors. In 1982 Marshall and Warren obtained funding for one year
of research. The first 30 out of 100 samples showed no support for their
hypothesis. However, it was discovered that the lab technicians had been
throwing out the cultures after 2 days. This was standard practice for
throat swabs where other organisms in the mouth rendered cultures as not
useful after 2 days. Due to other hospital work, the lab technicians did not
have time to immediately throw out the 31st test on the second day, and so
it stayed from Thursday through to the Monday. In this sample, they
discovered the presence of H. pylori. It turns out that H.
pylori grow more slowly than 2 days, and also that the stomach cultures
are not contaminated by other organisms. After his work at Fremantle Hospital, Marshall did research at Royal Perth Hospital (1985–86) and at the University of Virginia, USA (1986–present), before returning to Australia while remaining on the faculty of the University of Virginia. He held a Burnet Fellowship at the University of Western Australia (UWA) from 1998–2003. Marshall continues research related to H. pylori and runs the H. pylori Research Laboratory at UWA. Professor Marshall returned to Perth and UWA in 1996 after a tenure at the
University of Virginia. Today, Professor Marshall is the Director of The
Marshall Centre for Infectious Diseases Research and Training, which was
founded in his honour. In addition to H. pylori research, the Marshall
Centre is at the forefront of infectious disease identification and
surveillance, diagnostics and drug design, and transformative discovery. In 2007, Marshall accepted a part-time appointment at the Pennsylvania State University. Awards Prior to winning the Nobel Prize, Marshall had received the Albert Lasker Clinical Medical Research Award (1995) and the Benjamin Franklin Medal (1999) for his work on H. pylori. He also wrote several books, including Helicobacter Pioneers (2002), a collection of historical first-hand accounts of scientists who studied Helicobacter. Marshall also received the Warren Alpert Prize in 1994;
the Australian Medical Association Award and the Albert Lasker Award for
Clinical Medical Research in 1995; the Gairdner Foundation International
Award in 1996; the Paul Ehrlich and Ludwig Darmstaedter Prize in 1997; the
Golden Plate Award of the American Academy of Achievement, the Dr A.H.
Heineken Prize for Medicine, the Florey Medal, and the Buchanan Medal of the
Royal Society in 1998. Also, the Keio Medical Science Prize in 2002; and the Australian Centenary Medal and Macfarlane Burnet Medal and Lecture in 2003. Marshall was appointed a Companion of
the Order of Australia in 2007. He was awarded an honorary Doctor of Science
degree by the University of Oxford in 2009. These Days These days, apart from his duties as a Nobel laureate, university professor, researcher, medical doctor and renowned speaker, Prof. Marshall devotes time to his own bio tech startup, Ondek, which is developing products that use Helicobacter pylori bacterium to cure allergies. In August 2020 Barry Marshall, along with Simon J. Thorpe, accepted a position at the scientific advisory board of Brainchip INC, a computer chip company.
YouTube: Noisy Guts Project YouTube: Barry Marshall at GYSS 2023 – How bad luck, incompetence & fraud, delayed a discovery by 100 years - you will need to advance to 7mins as there was technical difficulties at the beginning. https://youtu.be/EDN0-0OKLFc YouTube: Professor Barry Marshall - Nobel Laureate https://youtu.be/63RCCKt4bQI YouTube: What Really Causes Ulcers- The Fascinating Saga of Nobel Prize Winner Dr. Barry Marshall https://youtu.be/hDP8jQnOcSg YouTube: How to win a Nobel Prize https://youtu.be/wvjAvkaWV7Y YouTube: The Man Who Tried to Give Himself An Ulcer... For Science https://youtu.be/HP6Zf1ff7Sw YouTube: Dr Barry Marshall Helicobacter Presentation https://youtu.be/Hn15vlR3IFM YouTube: The Barry J Marshall Library: UWA Science Library renamed in Nobel Laureate's honour https://youtu.be/AO1T-NhcVoU Community of Inquiry: Scientific Proof Middle Secondary
Australian
Curriculum General Capability:
Critical and creative thinking Australian Curriculum General Capability: Numeracy Australian Curriculum General Capability: Ethical Understanding Philosophy Cooperative Learning Activity
1. As a class, you are going to conduct a Community of Inquiry. Read over the structure and process of a CoI before commencing this activity. 2. Your stimulus material is an article written in July 2019 and the YouTube videos above. Split up the resources so all the class as different aspects to this discussion. 3. As a class group, read through the article above paragraph by paragraph. 4. In pairs, write up a question for each of the four quadrants below:
5. Put all the "Questions for Thinking" on a piece of butcher's paper or the board and collate those questions that seem to be asking the same thing. The question which is asked most, starts off the classroom discussion.
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